C96.21
BillableAggressive systemic mastocytosis
C96.21 is the ICD-10-CM code for Aggressive systemic mastocytosis. It is a billable, specific code valid for reimbursement.
C00-D49 Neoplasms
What this means — in plain language
MedlinePlus · NIHSystemic mastocytosis is a blood disorder that can affect many different body systems. Individuals with the condition can develop signs and symptoms at any age, but it usually appears after adolescence. Signs and symptoms of systemic mastocytosis often include extreme tiredness (fatigue), skin redness and warmth (flushing), nausea, abdominal pain, bloating, diarrhea, the backflow of stomach acids into the esophagus…
Read more about Systemic mastocytosis at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Medications indicated for this condition
FDA labelingDrugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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