C96.5

Billable

Multifocal and unisystemic Langerhans-cell histiocytosis

C96.5 is the ICD-10-CM code for Multifocal and unisystemic Langerhans-cell histiocytosis. It is a billable, specific code valid for reimbursement.

Status
Billable
Chapter
C00-D49
Parent
C96
Edition
FY2026

C00-D49 Neoplasms

What this means — in plain language

MedlinePlus · NIH

Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow. In Langerhans cell histiocytosis, excess immature Langerhans cells usually form tumors called granulomas. Many…

Read more about Langerhans cell histiocytosis at MedlinePlus ↗

Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.

Includes

  • Hand-Schüller-Christian disease
  • Histiocytosis X, multifocal

Excludes1 — not coded here

  • multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis (C96.0)
  • unifocal Langerhans-cell histiocytosis (C96.6)

Medications indicated for this condition

FDA labeling

Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.

Frequently asked questions

What is ICD-10 code C96.5?
C96.5 is the ICD-10-CM code for "Multifocal and unisystemic Langerhans-cell histiocytosis". It falls under C00-D49 Neoplasms.
Is C96.5 a billable code?
Yes — C96.5 is a billable, specific ICD-10-CM code valid for reimbursement.
What is excluded from C96.5?
Excludes1 (not coded here): multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis (C96.0); unifocal Langerhans-cell histiocytosis (C96.6).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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