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E22

Non-billable

Hyperfunction of pituitary gland

E22 is the ICD-10-CM code for Hyperfunction of pituitary gland. It is a non-billable category code — use a more specific child code such as E22.0 for billing.

Status
Header (non-billable)
Chapter
E00-E89
Subcodes
5
Edition
FY2026

E00-E89 Endocrine, nutritional and metabolic diseases

What this means — in plain language

MedlinePlus · NIH

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the master control gland - it makes hormones that affect growth and the functions of other glands in the body. With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor .

Read more about Pituitary Disorders at MedlinePlus ↗

Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.

Excludes1 — not coded here

  • •Cushing's syndrome (E24.-)
  • •Nelson's syndrome (E24.1)
  • •overproduction of ACTH not associated with Cushing's disease (E27.0)
  • •overproduction of pituitary ACTH (E24.0)
  • •overproduction of thyroid-stimulating hormone (E05.8-)

Medications indicated for this condition

FDA labeling

Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.

Frequently asked questions

What is ICD-10 code E22?
E22 is the ICD-10-CM code for "Hyperfunction of pituitary gland". It falls under E00-E89 Endocrine, nutritional and metabolic diseases.
Is E22 a billable code?
No — E22 is a non-billable header code. Use a more specific child code (such as E22.0) for billing.
What are the subcodes of E22?
E22 has 5 more specific child codes, including E22.0, E22.1, E22.2.
What is excluded from E22?
Excludes1 (not coded here): Cushing's syndrome (E24.-); Nelson's syndrome (E24.1); overproduction of ACTH not associated with Cushing's disease (E27.0); overproduction of pituitary ACTH (E24.0).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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