F33
Non-billableMajor depressive disorder, recurrent
F33 is the ICD-10-CM code for Major depressive disorder, recurrent. It is a non-billable category code — use a more specific child code such as F33.0 for billing.
- Status
- Header (non-billable)
- Chapter
- F01-F99
- Subcodes
- 7
- Edition
- FY2026
F01-F99 Mental, Behavioral and Neurodevelopmental disorders
A disorder characterized by repeated episodes of depression as described for depressive episode (F32.-), without any history of independent episodes of mood elevation and increased energy (mania). There may, however, be brief episodes of mild mood elevation and overactivity (hypomania) immediately after a depressive episode, sometimes precipitated by antidepressant treatment. The more severe forms of recurrent depressive disorder (F33.2 and F33.3) have much in common with earlier concepts such as manic-depressive depression, melancholia, vital depression and endogenous depression. The first episode may occur at any age from childhood to old age, the onset may be either acute or insidious, and the duration varies from a few weeks to many months. The risk that a patient with recurrent depressive disorder will have an episode of mania never disappears completely, however many depressive episodes have been experienced. If such an episode does occur, the diagnosis should be changed to bipolar affective disorder (F31.-).
What this means — in plain language
MedlinePlus · NIHWhat is depression? Depression is more than a feeling of being sad or irritable for a few days. It's a serious mood disorder . As one of the most common mental disorders in the United States, depression can affect how you think, feel, and your everyday life. You may not know why you feel this way, but even basic daily activities such as sleeping, eating, or working may become difficult. Depression often needs…
Read more about Depression at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Includes
- •recurrent episodes of depressive reaction
- •recurrent episodes of endogenous depression
- •recurrent episodes of major depression
- •recurrent episodes of psychogenic depression
- •recurrent episodes of reactive depression
- •recurrent episodes of seasonal affective disorder
- •recurrent episodes of seasonal depressive disorder
- •recurrent episodes of vital depression
Medications indicated for this condition
FDA labeling- Bupropion›
- Bupropion Hcl Er (xl)›
- Bupropion Hydrochloride (xl)›
- Olanzapine and FluoxetineAtypical Antipsychotic [EPC]›
- Olanzapine and FuoxetineAtypical Antipsychotic [EPC]›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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