I21
Non-billableAcute myocardial infarction
I21 is the ICD-10-CM code for Acute myocardial infarction. It is a non-billable category code — use a more specific child code such as I21.0 for billing.
- Status
- Header (non-billable)
- Chapter
- I00-I99
- Subcodes
- 8
- Edition
- FY2026
I00-I99 Diseases of the circulatory system
What this means — in plain language
MedlinePlus · NIHEach year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able to prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call…
Read more about Heart Attack at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Includes
- •cardiac infarction
- •coronary (artery) embolism
- •coronary (artery) occlusion
- •coronary (artery) rupture
- •coronary (artery) thrombosis
- •infarction of heart, myocardium, or ventricle
- •myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Excludes2 — not included here
Use additional code
- •code, if applicable, to identify:
- •exposure to environmental tobacco smoke (Z77.22)
- •history of tobacco dependence (Z87.891)
- •occupational exposure to environmental tobacco smoke (Z57.31)
- •status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
- •tobacco dependence (F17.-)
- •tobacco use (Z72.0)
Medications indicated for this condition
FDA labeling- TechnetiumRadioactive Diagnostic Agent [EPC]›
- LisinoprilThiazide Diuretic [EPC]›
- AtorvastatinHMG-CoA Reductase Inhibitor [EPC]›
- Atenololbeta-Adrenergic Blocker [EPC]›
- Clopidogrel›
- Enoxaparin›
- Dopamine›
- SimvastatinHMG-CoA Reductase Inhibitor [EPC]›
- TicagrelorP2Y12 Platelet Inhibitor [EPC]›
- ValsartanAngiotensin 2 Receptor Blocker [EPC]›
- Prasugrel›
- Pravastatin›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Conditions mapped to this code
MedlinePlus · NIHPlain-language health-topic references grounded in MedlinePlus (NIH/NLM).
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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