Z21

Billable

Asymptomatic human immunodeficiency virus [HIV] infection status

Z21 is the ICD-10-CM code for Asymptomatic human immunodeficiency virus [HIV] infection status. It is a billable, specific code valid for reimbursement.

Status
Billable
Chapter
Z00-Z99
Edition
FY2026

Z00-Z99 Factors influencing health status and contact with health services

What this means — in plain language

MedlinePlus · NIH

What is HIV? HIV stands for human immunodeficiency virus. HIV harms your immune system by destroying a type of white blood cell that helps your body fight infection. This puts you at risk for other infections and diseases. What is AIDS? AIDS stands for acquired immunodeficiency syndrome. It is the final stage of infection with HIV. It happens when the body's immune system is badly damaged because of the virus. Not…

Read more about HIV at MedlinePlus ↗

Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.

Includes

  • HIV positive NOS

Excludes1 — not coded here

  • acquired immunodeficiency syndrome (B20)
  • contact with human immunodeficiency virus [HIV] (Z20.6)
  • exposure to human immunodeficiency virus [HIV] (Z20.6)
  • human immunodeficiency virus [HIV] disease (B20)
  • inconclusive laboratory evidence of human immunodeficiency virus [HIV] (R75)

Code first

  • Human immunodeficiency virus [HIV] disease complicating pregnancy, childbirth and the puerperium, if applicable (O98.7-)

Frequently asked questions

What is ICD-10 code Z21?
Z21 is the ICD-10-CM code for "Asymptomatic human immunodeficiency virus [HIV] infection status". It falls under Z00-Z99 Factors influencing health status and contact with health services.
Is Z21 a billable code?
Yes — Z21 is a billable, specific ICD-10-CM code valid for reimbursement.
What is excluded from Z21?
Excludes1 (not coded here): acquired immunodeficiency syndrome (B20); contact with human immunodeficiency virus [HIV] (Z20.6); exposure to human immunodeficiency virus [HIV] (Z20.6); human immunodeficiency virus [HIV] disease (B20).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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