C49
Non-billableMalignant neoplasm of other connective and soft tissue
C49 is the ICD-10-CM code for Malignant neoplasm of other connective and soft tissue. It is a non-billable category code — use a more specific child code such as C49.0 for billing.
- Status
- Header (non-billable)
- Chapter
- C00-D49
- Subcodes
- 10
- Edition
- FY2026
C00-D49 Neoplasms
What this means — in plain language
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Includes
- •malignant neoplasm of blood vessel
- •malignant neoplasm of bursa
- •malignant neoplasm of cartilage
- •malignant neoplasm of fascia
- •malignant neoplasm of fat
- •malignant neoplasm of ligament, except uterine
- •malignant neoplasm of lymphatic vessel
- •malignant neoplasm of muscle
- •malignant neoplasm of synovia
- •malignant neoplasm of tendon (sheath)
Excludes1 — not coded here
Excludes2 — not included here
- •Kaposi's sarcoma of soft tissue (C46.1)
- •malignant neoplasm of heart (C38.0)
- •malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- •malignant neoplasm of peritoneum (C48.2)
- •malignant neoplasm of retroperitoneum (C48.0)
- •malignant neoplasm of uterine ligament (C57.3)
- •mesothelioma (C45.-)
Medications indicated for this condition
FDA labeling- Doxorubicin›
- Imatinib›
- Eribulin›
- Sunitinib›
- PazopanibKinase Inhibitor [EPC]›
- AtezolizumabProgrammed Death Receptor-1 Blocking Antibody [EPC]›
- Atezolizumab and Hyaluronidase-tqjsProgrammed Death Receptor-1 Blocking Antibody [EPC]›
- AvapritinibKinase Inhibitor [EPC]›
- CrizotinibKinase Inhibitor [EPC]›
- Imatinib Oral›
- Regorafenib›
- RipretinibKinase Inhibitor [EPC]›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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