D57.45
Non-billableSickle-cell thalassemia beta plus with crisis
D57.45 is the ICD-10-CM code for Sickle-cell thalassemia beta plus with crisis. It is a non-billable category code — use a more specific child code such as D57.451 for billing.
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
What this means — in plain language
MedlinePlus · NIHWhat is sickle cell disease (SCD)? Sickle cell disease (SCD) is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. This changes the shape of the red blood cells. The cells are supposed to be disc-shaped,…
Read more about Sickle Cell Disease at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Includes
- •HbS-beta plus with crisis
- •Sickle-cell beta plus with crisis
Medications indicated for this condition
FDA labeling- HydroxyureaAntimetabolite [EPC]›
- CrizanlizumabSelectin Blocker [EPC]›
- GlutamineAmino Acid [EPC]›
- VoxelotorHemoglobin S Polymerization Inhibitor [EPC]›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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