R65.21
BillableSevere sepsis with septic shock
R65.21 is the ICD-10-CM code for Severe sepsis with septic shock. It is a billable, specific code valid for reimbursement.
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
What this means — in plain language
MedlinePlus · NIHWhat is sepsis? Sepsis is your body's overactive and extreme response to an infection . Sepsis is a life-threatening medical emergency. Without quick treatment, it can lead to tissue damage, organ failure, and even death. What causes sepsis? Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Bacterial infections are the most common cause, but other types of infections…
Read more about Sepsis at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Excludes1 — not coded here
- •postprocedural septic shock (T81.12-)
Medications indicated for this condition
FDA labeling- Epinephrinealpha-Adrenergic Agonist [EPC]›
- TocilizumabInterleukin-6 Receptor Antagonist [EPC]›
- 6% Hetastarch in 0.9% Sodium ChloridePlasma Volume Expander [EPC]›
- albumin human, USP›
- angiotensin IIVasoconstrictor [EPC]›
- Epinephrine in Sodium Chloridealpha-Adrenergic Agonist [EPC]›
- Infant 4.2% Sodium Bicarbonate›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
- What is ICD-10 code R65.21?
- R65.21 is the ICD-10-CM code for "Severe sepsis with septic shock". It falls under R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
- Is R65.21 a billable code?
- Yes — R65.21 is a billable, specific ICD-10-CM code valid for reimbursement.
- What is excluded from R65.21?
- Excludes1 (not coded here): postprocedural septic shock (T81.12-).
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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