R65.2
Non-billableSevere sepsis
R65.2 is the ICD-10-CM code for Severe sepsis. It is a non-billable category code — use a more specific child code such as R65.20 for billing.
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
What this means — in plain language
MedlinePlus · NIHWhat is sepsis? Sepsis is your body's overactive and extreme response to an infection . Sepsis is a life-threatening medical emergency. Without quick treatment, it can lead to tissue damage, organ failure, and even death. What causes sepsis? Sepsis happens when an infection you already have triggers a chain reaction throughout your body. Bacterial infections are the most common cause, but other types of infections…
Read more about Sepsis at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Includes
- •Infection with associated acute organ dysfunction
- •Sepsis with acute organ dysfunction
- •Sepsis with multiple organ dysfunction
- •Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction
Code first
- •underlying infection, such as:
- •infection following a procedure (T81.4-)
- •infections following infusion, transfusion and therapeutic injection (T80.2-)
- •puerperal sepsis (O85)
- •sepsis following complete or unspecified spontaneous abortion (O03.87)
- •sepsis following ectopic and molar pregnancy (O08.82)
- •sepsis following incomplete spontaneous abortion (O03.37)
- •sepsis following (induced) termination of pregnancy (O04.87)
- •sepsis NOS (A41.9)
Use additional code
- •code to identify specific acute organ dysfunction, such as:
- •acute kidney failure (N17.-)
- •acute respiratory failure (J96.0-)
- •critical illness myopathy (G72.81)
- •critical illness polyneuropathy (G62.81)
- •disseminated intravascular coagulopathy [DIC] (D65)
- •encephalopathy (metabolic) (septic) (G93.41)
- •hepatic failure (K72.0-)
Medications indicated for this condition
FDA labeling- Epinephrinealpha-Adrenergic Agonist [EPC]›
- TocilizumabInterleukin-6 Receptor Antagonist [EPC]›
- 6% Hetastarch in 0.9% Sodium ChloridePlasma Volume Expander [EPC]›
- albumin human, USP›
- angiotensin IIVasoconstrictor [EPC]›
- Epinephrine in Sodium Chloridealpha-Adrenergic Agonist [EPC]›
- Infant 4.2% Sodium Bicarbonate›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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