R65.1
Non-billableSystemic inflammatory response syndrome (SIRS) of non-infectious origin
R65.1 is the ICD-10-CM code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin. It is a non-billable category code — use a more specific child code such as R65.10 for billing.
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Excludes1 — not coded here
- •sepsis- code to infection
- •severe sepsis (R65.2)
Medications indicated for this condition
FDA labeling- Epinephrinealpha-Adrenergic Agonist [EPC]›
- TocilizumabInterleukin-6 Receptor Antagonist [EPC]›
- 6% Hetastarch in 0.9% Sodium ChloridePlasma Volume Expander [EPC]›
- albumin human, USP›
- angiotensin IIVasoconstrictor [EPC]›
- Epinephrine in Sodium Chloridealpha-Adrenergic Agonist [EPC]›
- Infant 4.2% Sodium Bicarbonate›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
- What is ICD-10 code R65.1?
- R65.1 is the ICD-10-CM code for "Systemic inflammatory response syndrome (SIRS) of non-infectious origin". It falls under R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
- Is R65.1 a billable code?
- No — R65.1 is a non-billable header code. Use a more specific child code (such as R65.10) for billing.
- What is excluded from R65.1?
- Excludes1 (not coded here): sepsis- code to infection; severe sepsis (R65.2).
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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