R65.11
BillableSystemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
R65.11 is the ICD-10-CM code for Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction. It is a billable, specific code valid for reimbursement.
R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
Use additional code
- •code to identify specific acute organ dysfunction, such as:
- •acute kidney failure (N17.-)
- •acute respiratory failure (J96.0-)
- •critical illness myopathy (G72.81)
- •critical illness polyneuropathy (G62.81)
- •disseminated intravascular coagulopathy [DIC] (D65)
- •encephalopathy (metabolic) (septic) (G93.41)
- •hepatic failure (K72.0-)
Medications indicated for this condition
FDA labeling- Epinephrinealpha-Adrenergic Agonist [EPC]›
- TocilizumabInterleukin-6 Receptor Antagonist [EPC]›
- 6% Hetastarch in 0.9% Sodium ChloridePlasma Volume Expander [EPC]›
- albumin human, USP›
- angiotensin IIVasoconstrictor [EPC]›
- Epinephrine in Sodium Chloridealpha-Adrenergic Agonist [EPC]›
- Infant 4.2% Sodium Bicarbonate›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
- What is ICD-10 code R65.11?
- R65.11 is the ICD-10-CM code for "Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction". It falls under R00-R99 Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
- Is R65.11 a billable code?
- Yes — R65.11 is a billable, specific ICD-10-CM code valid for reimbursement.
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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