D89.4
Non-billableMast cell activation syndrome and related disorders
D89.4 is the ICD-10-CM code for Mast cell activation syndrome and related disorders. It is a non-billable category code — use a more specific child code such as D89.40 for billing.
D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Excludes1 — not coded here
- •aggressive systemic mastocytosis (C96.21)
- •congenital cutaneous mastocytosis (Q82.2)
- •(non-congenital) cutaneous mastocytosis (D47.01)
- •(indolent) systemic mastocytosis (D47.02)
- •malignant mast cell neoplasm (C96.2-)
- •malignant mastocytoma (C96.29)
- •mast cell leukemia (C94.3-)
- •mast cell sarcoma (C96.22)
- •mastocytoma NOS (D47.09)
- •other mast cell neoplasms of uncertain behavior (D47.09)
- •systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
Medications indicated for this condition
FDA labeling- Belumosudil›
- Betamethasone Sodium Phosphate, Betamethasone Acetate, Lidocaine, Povidine Iodine›
- EmapalumabInterferon gamma Blocker [EPC]›
- IbrutinibKinase Inhibitor [EPC]›
- remestemcel-L›
- Rilonacept›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Frequently asked questions
- What is ICD-10 code D89.4?
- D89.4 is the ICD-10-CM code for "Mast cell activation syndrome and related disorders". It falls under D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism.
- Is D89.4 a billable code?
- No — D89.4 is a non-billable header code. Use a more specific child code (such as D89.40) for billing.
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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